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Papaverine is a vasodilator, which causes blood vessels to expand and helps produce an erection by allowing the increase of blood flow to the penis

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For gut-specific endpoints, local mucosal exposure is sufficient for effect even without systemic absorption, because the target tissue (GI lining) is already in direct contact with the compound

5.2 The hormetic effect of sulforaphane Hormesis is a phenomenon characterized by a biphasic dose or concentrationresponse, where low doses or concentrations of a compound can stimulate a beneficial effect, while high doses or concentrations can lead to inhibitory effects (70)