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Sleep disturbance is an important bridge connecting constipation and depression, with research indicating that most comorbid patients experience sleep quality issues including difficulty initiating sleep, early awakening, and sleep fragmentation (Vege et al., 2004)

For musculoskeletal applications, research by Novinscak et al

The specific advice on the best time to take your chosen supplements will depend on the type of vitamin you're dealing with: fat-soluble or water-soluble