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then, primary bile acids are metabolized to secondary bile acids by 7-dehydroxylase ( Clostridium and Eubacterium , which also increases their abundance and can contribute to gallstone formation by increasing secondary bile acid production ( Although current clinical studies have demonstrated a correlation between PPIs and cholelithiasis, the specific effect of PPI-induced changes in the intestinal flora on cholelithiasis remains unclear

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Vitamin B1, B2, B6, B12, Niacinamide, and D-Panthenol work synergistically to enhance neurological function, boost energy levels, and promote overall cellular health