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These data will also be collected following knee replacement at 3- and 6-month follow-ups.

Freezethaw cycles may: Affect molecular stability Increase aggregation risk in some formulations Reduce overall consistency of the solution Storage at 28C is typically preferred unless otherwise validated

Importantly, apoptosis of erythroid cells can be fine-tuned in stress conditions to ensure adequate erythropoiesis

This method involves four main steps: isolation by strong cation-exchange SPE, mild derivatization with pentafluorophenyl trifluoromethanesulfonate, chromatographic separation using sequential ion-exchange/reversed-phase (ultra) high-performance liquid chromatography [(U)HPLC], and detection by electrospray ionization MRM-MS