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doi:10.3390/md13042196

ID8 Trp53 / model of ovarian cancer For the ovarian cancer experiments, C57BL/6J female mice (67 weeks old) were purchased from Charles River Laboratories UK (RRID: IMSR_JAX:000664) and allowed to acclimatize for at least 1 week before any regulated procedures were performed

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In acute myeloid leukemia cells, reduced MTHFR function, whether due to polymorphisms or pharmacologic inhibition, decreases intracellular SAM, leading to loss of the repressive histone marks H3K27me3 and H3K9me3 and de-repression of transcription factors such as SPI1 (85)