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In its response [15], the ACOG concluded that available studies show no clear evidence that proves a direct relationship between the prudent use of APAP during any trimester and fetal developmental issues. The ACOG further concluded that physicians should not change clinical practice until definitive prospective research is done. Considering the ACOG response, it is important to note that evidence of APAP inducing neurodevelopmental problems during the prenatal period is concerning but limited [2,16,17]

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Absorption kinetics are broadly similar across the three permitted sites, though there is some evidence from GLP-1 pharmacokinetic literature that abdominal subcutaneous delivery produces slightly faster peak concentration compared to thigh or arm administration

It is not authorized for human therapeutic use