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Real-world evidence suggests favorable cardiovascular effects, with some retrospective analyses showing tirzepatide may reduce major cardiovascular events by approximately 14% compared to semaglutide

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The team suggests their findings point to repurposing anti-diabetic weight loss-inducing drugs including semaglutide, dulaglutide, and liraglutide (glucagon-like peptide-1 receptor agonists), empagliflozin (a sodium-glucose cotransporter-2 inhibitor), and metformin (a biguanide), for MS

2 GLP-1RAs taken once weekly may take four to five weeks to achieve steady state, while clinical effectiveness may be longer depending on many factors such as age, sex, body weight, and liver and kidney function