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Cell culture studies using adipocytes have shown that NNMT overexpression promotes lipid accumulation and insulin resistance, while NNMT knockdown or inhibition increases NAD+ levels, activates SIRT1, enhances mitochondrial respiration, promotes expression of thermogenic genes including UCP1, and drives white adipocyte browning toward a beige phenotype

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Retinoids (retinol) and corticosteroids should be avoided for 1-2 weeks before and after treatment, to avoid over-stimulation of the skin as it prepares and recovers from the laser treatment