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So there's some theory that it is a direct effect on the heart and muscle, but there's actually very good evidence that some of that effect, at least, is due to the weight-losing effect

However, the effects of a creatine-carnitine combination on tangible improvements in athletic performance have not been scientifically proven

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While certainly not outweighing the good these medications offer, prescribing physicians need to keep in mind the real and serious ocular adverse events that may occur, he concluded.