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(He left the company in 2003, in part because he felt the company didnt then prioritize obesity treatments or see the benefit of an injectable weight-loss drug.) Following a once-weekly subcutaneous injection of retatrutide, participants in clinical trials exhibited a significant reduction in body weight and improvement of metabolic markers. Data collected in a phase II trial showed that obese participants lost a mean average of 24.2 percent of their body weight over a 48-week period

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However, the main concern with oral delivery is bioavailability, or how much of the peptide is absorbed into the bloodstream after digestion