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[2023] observed a reduction in median monthly headache days at 6 months in those treated with GLP-1RAs [4

A similar safety profile was observed in the SURMOUNT-2 randomized trial of tirzepatide in adults with obesity and T2DM where GIT adverse events were the most frequently reported with no data on neuro or psychiatric adverse events available [15]

Physical activity, particularly through resistance and aerobic training modalities, catalyzes angiogenesis, augments endothelial functionality, and stimulates anabolic signaling cascades, thereby enhancing muscle protein synthesis (MPS) and metabolic adaptability (7, 8)

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