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Based on our data, I would advise exercising particular caution when prescribing GLP-1 RAs to older [diabetic] patients or those with a history of stroke, as both groups were found to have an even higher risk of developing [the condition]. In an accompanying editorial, Brian VanderBeek, an associate professor of ophthalmology at the Hospital of the University of Pennsylvania, said the findings suggested that large numbers of patients could be affected

Importantly, this cluster can be competed out of SLC25A39 with GSH, destabilizing the protein under high GSH conditions 66,67

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Retatrutide does not directly stimulate muscle protein synthesis like anabolic compounds