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The NIH has not established a tolerable upper intake level because of the very low potential for toxicity

doi: 10.1016/J.FOODRES.2022.111798 56

(2021) reported a decrease in TNF- levels following the injection of GSH in a male rat peritonitis model

therefore, it must be transported into the cells by SLC7A11 (xCT) in exchange for glutamate, which implies that SLC7A11-mediated GSH biosynthesis largely relies on glutamine metabolism 55