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Following the success and approval of tirzepatide (Mounjaro, Eli Lilly, Indianapolis, IN, USA) in 2022 by FDA for treatment of T2DM, the SURMOUNT programme investigated its use as an anti-obesity medication in those without diabetes

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Notably, the ALKIVIA study also demonstrated positive phase II/III results for VYVGART Hytrolu within idiopathic inflammatory myopathies, triggering its further development within this indication [253], for which efgartigimod is the FcRn antagonist with the most advanced clinical program as of January 2025