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Drug-Target Complex Each molecule of the DPP-4 enzyme is a transmembrane glycoprotein made up of 766 amino acids and consists of five regions: a cytoplasmic region (residues 16) not crystallized/not shown a trans-membrane region (residues 728) not crystallized/not shown a highly-glycosylated region (residues 29323) colored cyan a cysteine-rich region (residues 324551) colored pink a catalytic region (residues 552766) colored orange The overall structure of the extracellular portion of the enzyme, showing the highly glycosylated, cysteine-rich, and catalytic regions can be seen in Figure 2

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The addition of alcohol may worsen these issues as its impact on the kidneys impairs the bodys ability to regulate fluid and electrolytes