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Monitoring and assessment Regardless of protocol, regular monitoring should include: Cognitive testing at baseline and regular intervals (MMSE, MoCA, or ADAS-cog) Vital signs during and after each administration session Hepatic and renal function panels (baseline and periodic) Neurological examination for seizure risk assessment Self-reported side effects diary Track progress using standardized scales

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In the second, lipidated, analogue, G002, the N-terminal was conjugated with trans-3-hexenoic acid, and in position 14, leucine was replaced by octyl glycine