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Some clinical data suggest that the 15mg dose may be associated with greater reductions in HbA1c and more pronounced weight changes compared to lower doses in some patients

Severe gastroparesis : Whilst delayed gastric emptying is expected, severe cases may present with persistent vomiting, inability to tolerate oral intake, significant weight loss beyond expected therapeutic effect, and severe abdominal distension

Previous versions of the ondansetron labels included a warning about QT interval prolongation

The FDA boxed warning is based on precautionary findings from animal studies where rodents developed thyroid C-cell tumors