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Mechanistically, it inhibits glycolysis and mitochondrial hyperactivation in CD4 + T cells, thereby suppressing Th1/Th17 cell differentiation and promoting Treg cell expansion (221, 248)

Top-Down Approach The top-down approach used macro-level indicators: Parent market benchmarks Global/regional industry trends Economic indicators (GDP, demographics, spending patterns) Penetration and usage ratios This approach was used for segments where granular data were limited or inconsistent

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