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However, while GST mediates detoxification from accidental xenobiotics, like exposures to pesticide for example, GSTs have also been implicated in the development of resistance toward chemotherapy agents, especially platinum-based chemotherapy drugs

Furthermore, the key ferroptosis regulatory inhibitor GPX4 of the antioxidant system and its upstream regulatory target GSH expression were suppressed, and the cytotoxicity of EMFF against granulosa cells could be attenuated by an iron chelator and ferroptosis inhibitor but not by the apoptosis, necrosis, and autophagy inhibitor

Ive been prescribed glutathione tablet form, a MyEczemaTeam member wrote

One of the main autoimmune disorders associated with this therapy is the development of autoimmune hypophysitis and isolated adrenocorticotropic hormone (ACTH) deficiency (67)