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As mentioned, a key component of spadin's rapid action might involve the activation of CREB, which may involve a specific link between CREB activation and hippocampal neurogenesis

Jeong S-H, Jang J-H, Cho H-Y, Lee Y-B (2020) Risk assessment for humans using physiologically based pharmacokinetic model of diethyl phthalate and its major metabolite, monoethyl phthalate