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10.3390/ijms24108874 30 ColomboA.FontaniM.DragonettiC.RobertoD.WilliamsJ
There continues to be debate as to the best delivery system due to absorption issues
Emerging evidence has further demonstrated that exosomal Trx1 derived from hypoxic human stem cells activates mTOR complex 1 (mTORC1) signaling upon cellular internalization, exhibiting anti-ferroptotic and cardioprotective effects against doxorubicin-induced cardiotoxicity (84)
Further, it revealed that PI3k inhibitors blocked the enhanced post-synaptic transmission, suggesting this effect might be dependent on PI3k activation [13]
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