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Given its potent redox capabilities, and its high intracellular concentration and widespread distribution, its role as a potent defense mechanism against oxidative and electrophilic stress is well-established

Effectiveness can be more difficult to evaluate within that timeframe

Accordingly, despite losing 25% of their body mass, GLP-1MK-801-treated mice maintained an energy expenditure that was similar to that of vehicle-treated control mice and was therefore also significantly higher than the gradually decreasing energy expenditure observed in mice that were calorie-restricted to match the weight loss trajectory of GLP-1MK-801-treated mice

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