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When designing an amylin-analog it was important to address the aggregatory nature of this protein
Clinical evidence: A study published in the Journal of Clinical Endocrinology and Metabolism demonstrated that CJC-1295 increased mean GH concentrations by 2 to 10-fold and IGF-1 levels by 1.5 to 3-fold (Teichman et al., 2006)
Growth hormone regulation of p85 expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance
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