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Kantor T, et al

This scarcity of intracellular Gln hampers the synthesis of asparagine and proteins encoded by the mitochondrial genome, ultimately leading to ROS-induced apoptosis in tumor cells (45)

Ozempic is approved to treat type 2 diabetes, while Wegovy is approved for chronic weight management

Moreover, although most of the residues in the ECDTMD interface are hydrophilic, we did not observe any hydrogen bond interactions between the two domains