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These volumetric deficits correlate with functional impairments: positron emission tomography (PET) scans reveal hypometabolism in the dorsolateral PFC and hyperactivation of the amygdala during negative emotional stimuli, mirroring neural signatures observed in non-alcoholic MDD patients (Amico et al

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The results showed that the combination of GIP and GLP-1 had an additive effect by suppressing bone resorption markers (74, Fig