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Second, competitive depletion of arginine suppresses T cell immunoreactivity, e.g., glioblastoma depletes arginine from the microenvironment through upregulation of arginase (ARG1), leading to inactivation of CD8 + T cell function and promoting immune escape(Mart and Reith 2021)

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Seek immediate medical attention if you experience severe persistent abdominal pain (especially if radiating to your back), persistent vomiting, inability to keep fluids down, dark urine, dizziness, fainting, fever, or yellowing of the skin or eyes