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This honest framing matters because treatment recommendations should be calibrated to the strength of evidence behind them

GLP1R expression differences between females and males Our finding of a consistent sex difference in the adverse effects of GLP1R agonists (after adjusting for differences in weight loss efficacy) across three species raises the possibility of inherent, sex-dependent differences in responsiveness of GLP1R-expressing neurocircuitry

Follow more conservative BUD guidelines

Peptides that interfere with myostatin signaling are studied in the context of muscular dystrophy and sarcopenia research models