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A naturally occurring antioxidant, GPX provides the main endogenous antioxidant protection against LPO in the epididymis and testes.[33] Through scavenging lipid peroxides and hydrogen peroxide (H 2 O 2 ), these enzymes confer protection for lipid constituents, thus preserving sperm viability and motility.[34] Studies have confirmed the presence of significantly reduced levels of GPX in infertile men as compared to fertile controls.[35] A few studies to date that have investigated the role of GSH on male infertility and have demonstrated a generally positive effect on semen parameters.[12,13,14] In a placebo-controlled, double-blind, cross-over trial, 600 mg of GSH administered intramuscularly every other day for 2 months led to an improvement in sperm motility and morphology in 20 men with varicocele or male germ-free genital tract inflammation.[13] In vitro studies have confirmed the protective effect of glutathione reductase on tail-beat frequency, LPO reduction, and improvement of sperm membrane characteristics.[36] GSH is poorly absorbed from the gastrointestinal tract making its preferred parenteral method of administration a major drawback to its widespread use

Clin Sports Med.2012;31:255262

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