glp 1 once weekly injection Another Weight-Loss Trial Win for GLP-1 Drug GLP-1s: What you need to

The Journal of Clinical Investigation, 131(10), e143770

Indeed, our single-cell RNA-seq (scRNA-seq) study in human islets found that transcripts that regulate alpha-cell maturity, such as ARX and DNMT1 , are differentially expressed across alpha-cell subpopulations, in which pseudotime analysis suggested that certain subpopulations are more mature than others (70), we found that the most immature subpopulation of alpha-cells also exhibited the highest expression of PCSK1 (gene name for PC1/3) ( PCSK1 -expressing alpha-cell subpopulation in response to intra-islet GLP-1R signaling (7478)

Some observational data suggest possible benefit, but randomized trials have not confirmed a direct protective effect

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