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& Tolosa, E

Lowered Quality of Life: Chronic pain can lead to frustration and decreased enjoyment of lifes activities

This leads to the development of malignant tumors, like hepatocellular carcinoma (HCC) (Gerdemann et al

When alcohol is removed, the result is a brain in a state of heightened excitation, producing anxiety, restlessness, irritability, and the intense urge to drink that constitutes an alcohol craving