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Elevated fatty acids (FAs) activate Toll-like receptors (TLRs) in macrophages, which act in synergy with MSU crystals to trigger NLRP3 inflammasome activation and pro-inflammatory cytokine release (e.g., IL-1), thereby initiating the inflammatory cascade

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Quick definition: Leaky gut refers to increased intestinal permeability a more porous gut barrier that lets bacterial fragments, undigested food particles, and toxins cross into deeper tissue more readily