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The mechanism is not well established it may relate to individual sensitivity, dehydration coinciding with supplement use, or other unrelated factors

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It causes an immediate release of almost all the granules (containing serotonin, histamine, chemokines, cytokines, enzymes, heparin, and prostaglandins), which trigger itching, swelling, mucous, and anaphylaxis.[ref] A delayed response by mast cells comes from the formation of other mediators, such as prostaglandin D2

Methyltransferases catalyze the methylation of Sterigmatocystin to O-methylsterigmatocystin