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In silico modelling suggests that rs146558 is a nonsynonymous single nucleotide polymorphism that leads to disruption in protein function
Classification [edit] Protein families that serve as peroxidases include: [1] Haem-using Non-heme Thiol: glutathione peroxidase, peroxiredoxin vanadium bromoperoxidase Alkyl hydroperoxide reductase Manganese peroxidase NADH peroxidase Characterization [edit] The glutathione peroxidase family consists of 8 known human isoforms
Primary Handling Editor: Ashley Castellanos-Jankiewicz, in collaboration with the Nature Metabolism team
Potential candidates include lipid peroxidation byproducts, such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), which are indicative of oxidative damage (104)
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