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A landmark 1989 RCT of 170 patients with cirrhosis (many with alcoholic etiology) found that 420 mg silymarin daily for a mean of 41 months significantly reduced overall mortality compared to placebo, with a more pronounced effect in the alcoholic cirrhosis subgroup, reporting a 58% four-year survival rate versus 39% in placebo (Ferenci, 1989) [32]

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Trimethylamine and trimethylamine N-Oxide, a flavin-containing monooxygenase 3 (FMO3)-Mediated host-microbiome metabolic axis implicated in health and disease

Metabolic profiling predicts response to anti-tumor necrosis factor therapy in patients with rheumatoid arthritis