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the peptide accumulates with consistent administration, and excess dosing increases side effect probability (temporary lethargy, localized injection site reaction) without improving tissue outcomes

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Ferguson LR, Browning BL, Huebner C, Petermann I, Shelling AN, Demmers P, McCulloch A, Gearry RB, Barclay ML, Philpott M: Single nucleotide polymorphisms in human Paneth cell defensin A5 may confer susceptibility to inflammatory bowel disease in a New Zealand Caucasian population