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The caspase-mediated cell death pathway has been widely implicated in programmed cell death of HCs (Nicotera et al., 2003

All treatments of mice in this study were in strict agreement with guidelines on ARRIVE and recommendations from an NIH-sponsored workshop regarding experimental design and reporting standards ( Cell Culture and Transfection RAW264.7 murine macrophage-like cells and THP-1 cells (human acute monocytic leukemia cell line) were obtained from the CBCAS (Cell Bank of the Chinese Academic of Sciences, Shanghai, China)

While GLP-1 clearly affects appetite centers in the brain, adding GIP agonism might influence different neural circuits related to food reward, energy expenditure, or metabolic regulation

This conservative approach reflects the principle that unproven medications should be avoided during pregnancy unless maternal health risks outweigh fetal uncertainties