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These are mechanisms described in published studies of the molecule, not human-use guidance Semaglutide is supplied for research only

Supplementary material The Supplementary Material for this article can be found online at: References 1 AgrawalG

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This is particularly relevant because bupropion carries an FDA boxed warning regarding seizure risk, and seizure threshold is lowered by several modifiable factors: abrupt alcohol or benzodiazepine discontinuation, eating disorders (anorexia nervosa, bulimia), electrolyte abnormalities, and conditions that cause metabolic disruption [2]