No human trial has shown Akkermansia to be a weight-loss treatment, and the same trial did not meet its main insulin-sensitivity goal across the group as a whole, with benefits showing up mainly in people who started with low Akkermansia levels or who had prediabetes
[DOI] [PubMed] [Google Scholar] 6.Crews FT, Collins MA, Dlugos C, Littleton J, Wilkins L, Neafsey EJ, Pentney R, Snell LD, Tabakoff B, Zou J, Noronha A
Some of my current work involves understanding that better. Some fiber-rich foods like leafy greens are inherently light and easy to digest, but others can be tougher, especially for GLP-1 diners
[1] These combined actions lead to improved glycemic control and significant weight reduction, with clinical trials in adults without diabetes demonstrating average weight loss of 15-22% of body weight over 72 weeks in the SURMOUNT-1 trial