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However, the inherent drawbacks of these inhibitors strongly limit their applications, such as insufficient affinity and selectivity for TYR, potential drug resistance, and dosing-associated toxicity

Kellerer, M., et al., Effect of once-weekly semaglutide versus thrice-daily insulin aspart, both as add-on to metformin and optimized insulin glargine treatment in participants with type 2 diabetes (SUSTAIN 11): A randomized, open-label, multinational, phase 3b trial

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