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In addition, pro-inflammatory cytokines can act to steal tryptophan away from serotonin and melatonin pathways (via up-regulation of the enzymes IDO and TDO), increasing the activity of the NMDA agonist quinolinic acid, and further antagonising stimulation of NMDA pathways, which subsequently exacerbates mood and sleep issues

These abnormalities persist even with a reduced metabolic rate, indicating that vulnerability arises mainly from impaired antioxidant defense rather than increased energy demand (110)

1-2 lux) resulted in increased NOS3 protein expression in the arteries after 2 weeks of exposure in male Wistar rats (Molcan et al., 2019)

A.) 357368 (Springer, 1981)