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Stepwise linear regression analysis found that the variations in initial BUN/Creatinine ratio could be partially predicted by urinary metal excretion at baseline and after the 9 th dose of Phase 1, with an adjusted R 2 = 0.35, p = 0.0001, with the most significant factors being baseline Sn (p = 0.003), baseline W (p = 0.02), and 9 th dose Sb (p = 0.05)

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