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They, therefore, have favourable effect on glucose metabolism and lead to significant caloric intake reduction and resultant weight reduction, usually in the vicinity of 3 - 8 kg depending on the dose and agent used

The effect of acylcarnitine on insulin sensitivity is also related to the saturation of acylcarnitine, with myotubes incubated with C16-carnitine exhibiting reduced insulin sensitization, whereas the accumulation of oleoylcarnitine (C18:1-carnitine) and linoleoylcarnitine (C18:2-carnitine) increases insulin sensitization [77]