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Reporting summary Further information on research design is available in the Nature Research Reporting Summary linked to this article

Findings were limited due to poor colonoscopy preparation, but resolving colonic ischemia was noted

While taking these medications, its recommended that patients follow a healthy diet and incorporate physical activity

When combined, these agents address multiple pathophysiologic defects simultaneously: metformin reduces basal hyperglycemia through hepatic mechanisms, while tirzepatide targets postprandial glucose elevations and promotes weight loss through central appetite regulation