Experimental and clinical data suggest increased AMPK activity, improved insulin sensitivity, and modulation of mTOR-related signaling, patterns that overlap with metabolic adaptations observed during caloric restriction [11,12]
It helps regulate the immune system, reduce inflammation, and improve metabolic function
[DOI] [PubMed] [Google Scholar] 60.Ligumsky H, Wolf I, Israeli S, Haimsohn M, Ferber S, Karasik A, et al
In summary, this investigation has unveiled the existence of a newly characterised inter-organelle signalling hub in pancreatic -cells which involves active endosomal GLP-1R localisation to ERMCSs via VAPB binding and engagement of the AKAP SPHKAP to enable ERMCS-restricted cAMP/PKA activity via the assembly of PKA-RI biomolecular condensates, leading to PKA phosphorylation of the MICOS complex, enhanced mitochondrial remodelling and improved mitochondrial function, with important implications for the modulation of -cell function and survival and the potential to serve as a mechanism for GLP-1R-induced mitochondrial adaptation during metabolic stress and excess nutrient exposure
