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[1] The International Society of Sports Nutrition identifies creatine monohydrate as the most effective supplement for increasing strength and lean mass with resistance training

JAMA Network Open, 2022 This retrospective study notes that patients who remained on lower doses of semaglutide experienced fewer side effectssuggesting that gradual titration and submaximal dosing may enhance tolerability without compromising outcomes

Anti-inflammatory effects on lab markers A 2025 meta-analysis of 52 randomised controlled trials in patients with type 2 diabetes (not RA) found that GLP-1 receptor agonists significantly reduced circulating levels of inflammatory compounds CRP, TNF-alpha, IL-6, and IL-1beta

Among these patients who both take a GLP-1 and have diabetes, the average age is 59.2, and 73.5% are commercially insured