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Efficacy and safety of early-start deferiprone in infants and young children with transfusion-dependent beta thalassemia: evidence for iron shuttling to transferrin in a randomized, double-blind, placebo-controlled, clinical trial (START)

If not reduced by the GPX system, lipid hydroperoxides can accumulate and decompose, yielding lipid peroxyl radicals (LOO*) and/or lipid alkoxyl radicals (LO*), which can amplify lipid peroxidation with the formation of additional lipid hydroperoxides [59]

Sun X, Deng Y, Fu X et al (2021) Angiv-analog dihexa rescues cognitive impairment and recovers memory in the app/ps1 mouse via the pi3k/akt signaling pathway

Then, 6-phosphogluconate dehydrogenase (PGD) that often functions as a homodimer catalyzes the oxidative decarboxylation of 6-phosphogluconate (6-PG) to synthesize ribulose-5-phosphate (Ru5P) and a second NADPH in the third reaction