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Speaking with MNT , Megan Warnke, RDN, a registered dietician nutritionist and Certified Diabetes Care and Education Specialist, also not involved in this research, explained that a very low-calorie diet is not viable approach beyond a short-term intervention: The key words in this study are short term results. Like with any diet, this approach may work for a short period of time, but its not sustainable for long term results. Also, appetite suppression from semaglutide can help patients follow a calorie-restricted diet, but other factors like stress, sleep, and food insecurity will also impact diet success, which is something this drug cant fix, Warnke explained