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When the cell has limited availability of nutrients, as in the case of caloric restriction, mTOR initiates mitophagy

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Concurrently, pro-inflammatory cytokines regulate the activity of key enzymes in tryptophan metabolismindoleamine IDO and TDOpromoting the production of kynurenine pathway metabolites such as KYNA

15 In the presence of ROS, rGSH is converted to GSSG by glutathione peroxidase (GPx) (Figure 3)