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Users stopping retinoids frequently report rapid regression of benefits within 4-8 weeks including increased breakouts sometimes exceeding pre-treatment levels (retinoid rebound), accelerated fine line reappearance approaching or surpassing baseline, skin texture deterioration returning to pre-treatment roughness, and psychological dependency from dramatic visible decline creating pressure for continuous use despite side effect burden

Redox Biol 11:2129

Composed of three amino acids cysteine, glycine, and glutamic acid its often referred to as the master antioxidant because it protects cells from oxidative stress and damage caused by free radicals

It is more appropriate to call diabetic complications as MDS-related target organ damage (TOD), since their development involves not only hyperglycemia but also other metabolic disorders of MDS, promoting an up-to-date management philosophy