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Whole aorta en face imaging showed that neither vehicle-treated nor semaglutide-treated groups exhibited reduced aorta plaque area compared with the baseline controls (Supplemental Figure 2B), even though semaglutide administration caused body weight loss but did not reduce liver or spleen weight (Supplemental Figure 2, C and D)

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Clinical Relevance: These findings explain GHK-Cu's accelerated wound closure observed in clinical settings and its interest as a therapeutic candidate for chronic wounds, post-surgical recovery, and tissue regeneration applications

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